One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, HPLC of Formula: C11H9NO5, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 69604-00-8, Name is Ethyl 5-nitrobenzofuran-2-carboxylate, molecular formula is C11H9NO5
The multifarious metabolic syndrome, diabetes mellitus (DM), is a diseaseof concern all over the world and is approximate to affect 400 million indi-viduals by the 2020. Several classes of drugs at the moment are avail-able to lessen hyperglycemia in diabetes mellitus especially in Type-II. These drugs mostly have dangerous side effects and thus incisive for a new class of compounds is necessary to conquer this inconvenience. A series of 6 novel 5-nitrobenzofuran-2yl-carbamides derivatives were synthesized and molecular docking studies were performed on PPAR-gamma target using (PDB code-4rfm).The preparation of5-nitro-1-benzofuran-2-carbohydrazide(4) on action with acetic acid, 1, 4-diaxone and sodium nitrite resulted in 5-nitro-1-benzofuran-2-carbonyl azide (5).The related compound (5) on action with substituted aromatic substituted amines undergoes Curtis type of rearrangement to give 5-nitro-N-(sub. carbamoyl)-1-benzofuran-2-carboxamide.The characterization and identification of prepared compounds were identified on the basis of NMR, IR, Mass and elemental analysis. Docking study of tar-geted compounds were done using software Autodock Tools 1.5.6 and visu-alisation done by Discovery Studio 3.5 software (Accelrys Inc. San Diego, CA USA). Molecular docking studies, the binding energies are determined to be in the range of ?5.90 to ?9.80 kcal/mol, with peroxisome proliferator activated receptor gamma (PPAR-gamma) receptors (PDB ID: 4RFM). The prepared compounds have been studied for their oral glucose tolerance test to distinguish the effect on plasma glucose level.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. HPLC of Formula: C11H9NO5, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 69604-00-8, in my other articles.
Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3875O – PubChem