Reference of 496-41-3, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 496-41-3, Name is Benzofuran-2-carboxylic acid,introducing its new discovery.
A contemporary method is reported for the Pd(OAc)2/AgOAc catalytic system based bidentate ligand directed, regioselective C-H activation and C-C bond formation at the C-3 position of thiophene- and furan-2-carboxamides, which are derived from 8-aminoquinoline or 2-(methylthio)aniline. The Pd-catalyzed C-H arylation of thiophene- and furan-2-carboxamides with a variety of aryl iodides and heteroaryl iodides was highly regioselective and afforded C-3-arylated thiophene-2-carboxamides and furan-2-carboxamides in good to very good yields. The bidentate ligand directed Pd(OAc)2/AgOAc based strategy was also successfully employed for benzylation and alkylation reactions of the thiophene-2-carboxamides. These reactions occurred with high regioselectivity to afford the C-3-benzylated and C-3-alkylated thiophene-2-carboxamides in good yields. The observed regioselectivity of these reactions was confirmed by X-ray crystal structure analyses of compounds 3e, 5a, and 6a. A contemporary method is reported for the Pd(OAc)2/AgOAc catalytic system based bidentate ligand directed, regioselective C-H activation and C-C bond formation of the C-3 position of thiophene- and furan-2-carboxamides. This protocol was used for the direct C-3 arylation and alkylation reactions of both thiophene- and furan-2-carboxamides.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 496-41-3, and how the biochemistry of the body works.Reference of 496-41-3
Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1919O – PubChem