54109-03-4, Name is 5-Chloroisobenzofuran-1(3H)-one, belongs to benzofurans compound, is a common compound. Safety of 5-Chloroisobenzofuran-1(3H)-oneIn an article, once mentioned the new application about 54109-03-4.
Rh-catalyzed direct carboxylation of unactivated aryl C-H bond under atmospheric pressure of carbon dioxide was realized via chelation-assisted C-H activation for the first time. Variously substituted and functionalized 2-arylpyridines and 1-arylpyrazoles underwent the carboxylation in the presence of the rhodium catalyst and a stoichiometric methylating reagent, AlMe 2(OMe), to give carboxylated products in good yields. The catalysis is proposed to consist of methylrhodium(I) species as the key intermediate, which undergoes C-H activation to afford rhodium(III), followed by reductive elimination of methane to give nucleophilic arylrhodium(I). This approach demonstrates promising application of C-H bond activation strategy in the field of carbon dioxide fixation.
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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2631O – PubChem