COA of Formula: C18H20N2O12. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about Reoxidation of the class I disulfides of the rat adipocyte insulin receptor is dependent upon the presence of insulin: the class I disulfide of the insulin receptor is extracellular. Author is Chiacchia, Kenneth B..
Elements of the quaternary structure of the native and dithiothreitol (DTT)-reduced rat adipocyte insulin receptor were elucidated by vectorial probing and subunit crosslinking. The charged reducing agents glutathione and β-mercaptoethylamine were used to reduce the class I disulfides of the receptor in intact adipocytes, demonstrating the extracellular location of the disulfide directly. This interpretation was confirmed by use of DTT as a reducing agent and the nonpermeant SH-blocking reagent Thiolyte MQ to prevent the reoxidation of the class I SH groups which occurred when they were not blocked. The above reoxidation of the receptor was dependent on the concentration of insulin in the nanomolar range, not occurring measurably at 4° in its absence. Crosslinking studies with ethylene glycol bis(succinimidyl succinate) demonstrated that the α-subunits could not be crosslinked to each other after reduction of the class I disulfides, suggesting that the interaction between the receptor heterodimers may be due primarily to the disulfide bonds.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem