Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Category: benzofurans, 66357-35-5, Name is Ranitidine, SMILES is O=[N+]([O-])/C=C(NCCSCC1=CC=C(O1)CN(C)C)NC, belongs to benzofurans compound. In a document, author is Yerrabelly, Jayaprakash Rao, introduce the new discover.
An Efficient and Scalable Synthesis of Lifitegrast
An efficient and improved synthesis of a novel anti-inflammatory drug, Lifitegrast 1 is described from Benzofuran-6-carboxylicacid. This synthetic approach avoided the racemization, formation of dimer impurities and furnished higher overall yield (79 %) with high purity. The key step of the synthesis involves tertiary butylester protection of the aminoacid fragment, which was hydrolyzed in further stages under mild acidic conditions. The critical process parameters were thoroughly studied for protection and deprotection of the tertiary butyl functional group. The attractive features of synthesis are the usage of commercially cheaper and eco-friendly reagents suitable for multi kilo scale synthesis of Lifitegrast 1.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 66357-35-5. Category: benzofurans.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem