Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 591-11-7, Name is 5-Methylfuran-2(5H)-one, molecular formula is C5H6O2, belongs to benzofurans compound. In a document, author is Eldehna, Wagdy M., introduce the new discover, Formula: C5H6O2.
Benzofuran-Based Carboxylic Acids as Carbonic Anhydrase Inhibitors and Antiproliferative Agents against Breast Cancer
Pursuing our effort for developing effective inhibitors of the cancer-related hCA IX isoform, here we describe the synthesis of novel benzofuran-based carboxylic acid derivatives, featuring the benzoic (9a-f) or hippuric (11a,b) acid moieties linked to 2-methylbenzofuran or 5-bromobenzofuran tails via an ureido linker. The target carboxylic acids were evaluated for the potential inhibitory action against hCAs I, II, IX, and XII. Superiorly, benzofuran-containing carboxylic acid derivatives 9b, 9e, and 9f acted as submicromolar hCA IX inhibitors with Kis = 0.91, 0.79, and 0.56 mu M, respectively, with selective inhibitory profile against the target hCA IX over the off-target isoforms hCA I and II (SIs: 2 to >63 and 4-47, respectively). Compounds 9b, 9e, and 9f were examined for their antiproliferative action against human breast cancer (MCF-7 and MDA-MB-231) cell lines. In particular, 9e displayed promising antiproliferative (IC50 = 2.52 +/- 0.39 mu M), cell cycle disturbance, and pro-apoptotic actions in MDA-MB-231 cells.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 591-11-7. Formula: C5H6O2.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem