Li, Wenxi’s team published research in Phytochemistry Letters in 40 | CAS: 56317-21-6

Phytochemistry Letters published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Category: benzofurans.

Li, Wenxi published the artcileNeoveratrol A-D: Four new arylbenzofurans from Veratrum nigrum, Category: benzofurans, the publication is Phytochemistry Letters (2020), 144-147, database is CAplus.

Four new arylbenzofurans, 2-(3,5dimethoxy) phenyl-6-hydroxy-7-methoxy benzofuran (1, Neoveratrol A), 2-(3-O-β-D-glucosyl-5-hydroxy) phenyl-4,6-dimethoxy benzofuran (2, Neoveratrol B), 2-(3,5-dimethoxy) phenyl-4-O-β-D-glucosyl-6-hyroxy benzofuran (3, Neoveratrol C), 2-(3,5-dimethoxy) phenyl-6-hydroxy-7-O-β-D-glucosyl benzofuran (4, Neoveratrol D), together with nine known ones (5-13) were isolated from the dried root and rhizome of a Traditional Mongolian medicinal herb Veratrum nigrum. The structures were elucidated by various spectroscopic methods including UV, IR, NMR and HR-MS. Among these compounds, 1-3, 5, 7-9 and 11-13 showed significant inhibitory effects on lipopolysaccharide (LPS) induced nitric oxide (NO) production in RAW264.7 cells at the concentration ranging from 50.0-200.0μM. Compound 1 exhibited moderate activity against HepG2 and HCT-15. In addition, compound 5 and 6 showed inhibitory activities against human tumor cell lines HepG2, HCT-15, A549, MDA-MB-231 and SH-SY5Y with IC50 range of 40-100μM.

Phytochemistry Letters published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Category: benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem