Multi-residue analysis of organic pollutants in hair and urine for matrices comparison was written by Hardy, Emilie M.;Duca, Radu C.;Salquebre, Guillaume;Appenzeller, Brice M. R.. And the article was included in Forensic Science International in 2015.Formula: C10H12O2 This article mentions the following:
Urine being currently the most classically used matrix for the assessment of human exposure to pesticides, a growing interest is yet observed in hair anal. for the detection of organic pollutants. The aim of the present work was to develop and to validate multi-residue anal. methods, as similar as possible, in order to determine pesticides and their metabolites in these two biol. matrixes despite their different nature. The list of parent compounds and their metabolites investigated here consisted of 56 compounds, including organochlorines, organophosphates, pyrethroids, carbamates, other pesticides and polychlorinated biphenyls (PCBs). Two different approaches were necessary for the anal. of non-polar compounds (mainly parents) on one hand and polar analytes (mainly metabolites) on the other hand. In the final procedure, extraction from hair was carried out with acetonitrile/water after sample decontamination and pulverization. Extract was split into two fractions, which were analyzed directly with solid phase microextraction (SPME) injection for non-polar compounds and after derivatization with liquid injection for polar compounds In urine, non-polar compounds were analyzed directly using SPME. Polar compounds were analyzed after acidic hydrolysis, liquid-liquid extraction with acetonitrile-cyclohexane-Et acetate, derivatization and liquid injection. Anal. was performed with gas chromatog. tandem mass spectrometry operating in neg. chem. ionization (GC-MS/MS-NCI) for all the compounds (non-polar and polar) in the two matrixes.In hair, limits of quantification (LOQ) ranged from 0.02 pg/mg for trifluralin to 5.5 pg/mg for diethylphosphate. In urine, LOQ ranged from 0.4 pg/mL for α-endosulfan to 4 ng/mL for dimethyldithiophosphate. The anal. of samples supplemented with standards and samples collected from an animal previously submitted to chronic exposure to pesticides confirmed that all the compounds were analyzable in both hair and urine. In addition, the levels of sensitivity reached with these methods were quite satisfactory with regard to previously published studies, and also considering the number of compounds investigated. In the experiment, the researchers used many compounds, for example, 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8Formula: C10H12O2).
2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Formula: C10H12O2
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem