A mild and efficient amidation of cyclic ethers catalyzed by rhodium caprylate was written by Gu, Ling-Hui;Zhang, Dan-Dan;Qi, Qing-Rong;Yin, Ping;He, Ling. And the article was included in Tetrahedron in 2014.Application In Synthesis of 5-Nitro-2,3-dihydrobenzofuran This article mentions the following:
A small quantity of Rh2(O2CC7H15)4 catalyzed the α-amidation of cyclic ethers under mild conditions, in the presence of electron-withdrawing p-chlorobenzenesulfonamide/PhI(OAc)2 as the nitrene source, in CH2Cl2. The corresponding N-substituted amino cyclic ethers were successfully obtained in good yields, e.g., I, and compatibility with other oxidant sensitive structures in one-pot reaction. In the experiment, the researchers used many compounds, for example, 5-Nitro-2,3-dihydrobenzofuran (cas: 17403-47-3Application In Synthesis of 5-Nitro-2,3-dihydrobenzofuran).
5-Nitro-2,3-dihydrobenzofuran (cas: 17403-47-3) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Application In Synthesis of 5-Nitro-2,3-dihydrobenzofuran
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem