Application of 127264-14-6, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 127264-14-6, Name is 5-(2-Bromoethyl)-2,3-dihydrobenzofuran,introducing its new discovery.
Synthesis/Isolation of darifenacin hydrobromide by-products
During the process development in the laboratory, the purity of darifenacin hydrobromide has been tested by HPLC. Three byproduct peaks along with darifenacin 1 peak have been observed whose area percentage ranged from 0.06-0.20% by HPLC. As per the stringent regulatory requirements, the by-products above threshold of ?0.1% must be identified and characterized. All thorough study has been undertaken to synthesize and characterize these identified by-products. All the synthesized/isolated compounds have been co-injected with darifenacin hydrobromide, the relative retention times (RRT) are found to exactly match with the identified by-products. Based on their analytical and spectral data (HPLC, IR, NMR and mass), these by-products have been characterized as (3S)-N, N-bis[2-(2,3-dihydro-1-benzofuran-5- yl)ethyl]-2,2-diphenyl-2-(pyrrolidin-3-yl)acetamide (dimer-1), (3S)-N-[2-(2,3-dihydrobenzofuran-5-yl)-ethyl]-2-{1-[2-(2,3-dihydrobenzofuran- 5-yl)-ethyl]-pyrrolidin-3-yl}-2,2-diphenyl-acetamide (dimer-2) and (3R)-2-{1-[2-(2,3-dihydrobenzofuran-5-yl)- ethyl]pyrrolidin-3-yl}-2,2- diphenylacetamide (R-isomer).
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 127264-14-6, and how the biochemistry of the body works.Application of 127264-14-6
Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3841O – PubChem