Exhaustive Reduction of Esters Enabled by Nickel Catalysis was written by Cook, Adam;Prakash, Sekar;Zheng, Yan-Long;Newman, Stephen G.. And the article was included in Journal of the American Chemical Society in 2020.Synthetic Route of C10H8O3 This article mentions the following:
A one-step procedure to directly reduce unactivated aryl esters into their corresponding tolyl derivs was reported. This was achieved by an organosilane-mediated ester hydrosilylation reaction and subsequent Ni/NHC-catalyzed hydrogenolysis. The resulting conditions provided a direct and efficient alternative to multi-step procedures for this transformation that often required the use of hazardous metal hydrides. Applications in the synthesis of -CD3-containing products, derivatization of bioactive mols., and chemoselective reduction in the presence of other C-O bonds were demonstrated. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Synthetic Route of C10H8O3).
Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Synthetic Route of C10H8O3
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem