Application of 70539-42-3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cells. Author is Anagnostou, Athanasius; Lee, Eun Sun; Kessimian, Noubar; Levinson, Rachel; Steiner, Manfred.
A dose-dependent proliferative action of human recombinant erythropoietin on human umbilical vein endothelial cells and bovine adrenal capillary endothelial cells was observed Binding studies with radioiodinated recombinant human erythropoietin revealed a large number (≈27,000) of an apparent single class of receptors with an affinity in the 10-9 M range. Linkage of the radiolabeled ligand to its receptor via a bifunctional crosslinking agent allowed identification of an endothelial cell protein of 45 kilodaltons as the principal receptor associated with this mitogenic effect of erythropoietin. Recombinant human erythropoietin also enhanced the migration of endothelial cells.
In addition to the literature in the link below, there is a lot of literature about this compound(Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate)Application of 70539-42-3, illustrating the importance and wide applicability of this compound(70539-42-3).
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem