Category: 69626-75-1

Varga, Balint published the artcileSynthesis and Photochemical Application of Hydrofluoroolefin (HFO) Based Fluoroalkyl Building Block, COA of Formula: C8H5IO, the publication is Organic Letters (2021), 23(12), 4925-4929, database is CAplus and MEDLINE.

A novel fluoroalkyl iodide, 3-chloro-1,1,1,2-tetrafluoro-2-iodopropane was synthesized on multigram scale from refrigerant gas HFO-1234yf as cheap industrial starting material in a simple, solvent-free, and easily scalable process. Here, its applicability in a metal-free photocatalytic ATRA reaction demonstrated to synthesize valuable fluoroalkylated vinyl iodides RCH(I)=CHC(F)(CF₃)CH₂Cl (R = n-Bu, Ph, pyridin-3-yl, etc.) and proved the straightforward transformability of the products in cross-coupling chem. to obtain conjugated systems R¹C(CCR²)=CHC(F)(CF₃)CH₂Cl (R¹ = Ph, n-Bu, 1-naphthyl, etc.; R² = n-Bu, TMS, Ph, 2-thienyl, etc.); R¹C(Ar)=CHC(F)(CF₃)CH₂Cl (Ar = Ph, furan-3-yl, 3-methyl-3H-imidazo[4,5-b]pyridine-6-yl, etc.).

Organic Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C7H5Br2F, COA of Formula: C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Kryska, Anna published the artcileImproved, acid-catalyzed iodinating procedures for activated aromatics with (diacetoxyiodo)benzene as the oxidant, Application of 2-Iodobenzofuran, the publication is Journal of Chemical Research, Synopses (1999), 590-591, 2501-2517, database is CAplus.

Activated aromatics are effectively converted, at room temperature and within 15 min, into the corresponding mono-, di- or tri-iodinated products in anhydrous I₂-PhI(OAc)₂-AcOH-Ac₂O systems, acidified with catalytic amounts of concentrate H₂SO₄.

Journal of Chemical Research, Synopses published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Application of 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Zhang, Dejiang published the artcileNickel- and Palladium-Catalyzed Cross-Coupling of Stibines with Organic Halides: Site-Selective Sequential Reactions with Polyhalogenated Arenes, SDS of cas: 69626-75-1, the publication is ACS Catalysis (2022), 12(2), 854-867, database is CAplus.

Herein, the authors disclose a general and efficient method for the synthesis of Sb-aryl and Sb-alkyl stibines by the Ni-catalyzed cross-coupling of halostibines with organic halides. The synthesized Sb-aryl stibines couple with aryl halides to give biaryls efficiently via Pd catalysis. Sequential reactions of stibines with polyhalogenated arenes bearing active C-I/C-Br sites and inactive C-Cl sites successfully proceeded, giving a variety of complex mols. with good site selectivity. Drugs such as diflunisal and fenbufen, as well as a fenofibrate derivative, were synthesized on gram scales in good yields, together with the high recovery of chlorostibine. Also, catalytic mechanisms are proposed based on the results of control experiments

ACS Catalysis published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C6H13NO2, SDS of cas: 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Haraguchi, Ryosuke published the artcilePalladium-Catalyzed Formylation of Arylzinc Reagents with S-Phenyl Thioformate, Safety of 2-Iodobenzofuran, the publication is Organic Letters (2017), 19(7), 1646-1649, database is CAplus and MEDLINE.

In the presence of Pd(OAc)₂ and tri(2-furyl)phosphine in toluene/THF, arylzinc reagents derived from aryl iodides and an alkenylzinc reagent were chemoselectively formylated with S-Ph thioformate PhSCHO to yield aryl aldehydes ArCHO (Ar = 4-NCC₆H₄, 4-EtO₂CC₆H₄, 4-i-Pr₂NCOC₆H₄, 4-ClC₆H₄, 4-BrC₆H₄, 3-ClC₆H₄, 3-BrC₆H₄, 4-MeOC₆H₄, 1,3-benzodioxol-5-yl, 4-HOC₆H₄, 4-Me₂NC₆H₄, 2-MeC₆H₄, 2-MeOC₆H₄, 2,4,6-Me₃C₆H₂, 2-naphthyl, 1-naphthyl, 2-thienyl, 2-benzofuranyl, 1-Me-5-indolyl) and trans-cinnamaldehyde in 56-97% yields. Using deuterated and ¹³C-labeled deuterated and ¹³C-labeled S-Ph thioformate, 4-DCOC₆H₄CN and 4-BrC₆H₄¹³CH:CH₂ were prepared in high isotopic purities by this method.

Organic Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Safety of 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Hong, Seung Youn published the artcileIr(III)-Catalyzed Stereoselective Haloamidation of Alkynes Enabled by Ligand Participation, Computed Properties of 69626-75-1, the publication is Journal of the American Chemical Society (2018), 140(39), 12359-12363, database is CAplus and MEDLINE.

Described herein is the application of a strategy of ligand participation for the Ir-catalyzed imido transfer into alkynes. On the basis of a stoichiometric [3 + 2] cycloaddition of Cp*Ir(III)(κ²-N,O-chelate) with alkynyl dioxazolone, a catalytic haloamidation was developed for the first time by employing [Cp*IrCl₂]₂ precatalyst and NaX salts (X = Cl or Br) as practical halide sources to furnish synthetically versatile Z-(halovinyl)lactams, e.g. I (R = cyclopropyl, 1-cyclohexenyl, Ph, 4-MeOC₆H₄, 2-benzothienyl, PhCC, etc.), from alkynyl dioxazolones, e.g. II, with excellent stereoselectivity.

Journal of the American Chemical Society published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Computed Properties of 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Guo, Zhengwei published the artcileSynthesis of reversible PAD4 inhibitors via copper-catalyzed C-H arylation of benzimidazole, Formula: C8H5IO, the publication is Science China: Chemistry (2019), 62(5), 592-596, database is CAplus.

A Cu-catalyzed C-H arylation reaction of N-heteroarene I [R = H; R¹ = H₃CO] has been applied to the synthesis of complex non-covalent PAD4 inhibitors I [R = 1-benzyl-1H-indol-2-yl, naphthalen-2-yl, pyrazin-2-yl, etc.; R¹ = (3S,4R)-3-amino-4-hydroxypiperidin-1-yl] bearing a bi-heteroaryl pharmacophore. This strategy access various analogs of C₂-aryl substituted benzimidazoles I [R¹ = OH, H₃CO] from a common benzimidazole core I [R = H; R¹ = H₃CO] and easily accessible aryl iodides RI. Preliminary SAR studies revealed that the indole motif of GSK-484 is critical to its activity. Replacing the N-cyclopropylmethyl group to N-benzyl group on the indole ring of GSK-484 resulted in more than 5-fold increase in cell killing efficacy against 4T1 cell line.

Science China: Chemistry published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Formula: C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Negishi, Ei-ichi published the artcileDirect synthesis of heteroarylethynes via palladium-catalyzed coupling of heteroaryl halides with ethynylzinc halides. Its application to an efficient synthesis of a thiophenelactone from Chamaemelum nobile L, Computed Properties of 69626-75-1, the publication is Heterocycles (1997), 209-214, database is CAplus.

A variety of terminal alkynes containing a heteroaryl group can be directly and selectively synthesized by the Pd-catalyzed coupling of heteroaryl iodides or bromides with ethynylzinc halides. Various compounds of this class containing furan, thiophene, and pyridine have been prepared, and the procedure has been applied to an efficient and selective synthesis of a thiophenelactone from Chamaemelum nobile L.

Heterocycles published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Computed Properties of 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Zhang, Fuyi published the artcileGeneral and efficient one-pot synthesis of novel sugar/heterocyclic(aryl) 1,2-diketones from sugar terminal alkynes by Sonogashira/tetra-n-butylammonium permanganate oxidation, HPLC of Formula: 69626-75-1, the publication is Carbohydrate Research (2015), 41-51, database is CAplus and MEDLINE.

A new approach for one-pot synthesis of novel sugar/heterocyclic(aryl) 1,2-diketones has been achieved by the reaction of various sugar terminal alkynes with heterocyclic(aryl) iodides at room temperature This one-pot protocol includes Sonogashira coupling and mild n-Bu₄NMnO₄ oxidation reaction. This method is mild, general and efficient. Fifty-six examples have been given and the sugar/heterocyclic(aryl) 1,2-diketones were obtained in 71-94% yields. The sugar terminal alkynes include 9 structurally different sugars in pyranose, furanose, and acyclic form which have various protecting groups, sensitive groups, and sterically bulky substituents. The heterocyclic(aryl) iodides include sterically bulky heterocyclic compounds and iodobenzenes with electron-donating, electron-neutral, and electron-withdrawing substituents.

Carbohydrate Research published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C10H16Br3N, HPLC of Formula: 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Wen, Chang published the artcileHighly Efficient Synthesis of 2-Substituted Benzo[ b ]furan Derivatives from the Cross-Coupling Reactions of 2-Halobenzo[ b ]furans with Organoalane Reagents, COA of Formula: C8H5IO, the publication is Synthesis (2021), 53(20), 3847-3861, database is CAplus.

A highly efficient and simple route for the synthesis of benzo[ b]furans was developed by palladium-catalyzed cross-coupling reaction of 2-halobenzo[ b]furans with aryl, alkynyl, and alkylaluminum reagents. Various 2-aryl-, 2-alkynyl-, and 2-alkyl benzo[ b]furans was obtained in 23-97% isolated yields using 2-3 mol% PdCl 2/4-6 mol% XantPhos as the catalyst under mild reaction conditions. The aryls beared electron-donating or electron-withdrawing groups in 2-halobenzo[ b]furans gave products in 40-97% isolated yields. In addition, aluminum reagents containing thienyl, furanyl, trimethylsilanyl, and benzyl groups worked efficiently with 2-halobenzo[ b]furans as well, and three bioactive mols. with benzo[ b]furans skeleton were synthesized. Furthermore, the broad substrates scope and the typical maintenance of vigorous efficiency on gram scale made this protocol a potentially practical method to synthesize benzo[ b]furans. On the basis of the exptl. results, a possible catalytic cycle was proposed.

Synthesis published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C22H32O2, COA of Formula: C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Mann, Inderjit S. published the artcileTransition metal-directed synthesis of moracin M, a phytoalexin of Morus alba Linn, Safety of 2-Iodobenzofuran, the publication is Tetrahedron (1991), 47(37), 7981-90, database is CAplus.

2-(5-Resorcinyl)benzofurans have been synthesized by the Pd-catalyzed cross-coupling of 2-trimethylstannyl- or 2-bromozincbenzofurans with functionalized 5-iodoresorcinols. These were synthesized by the triisopropylsilyloxy-directed remote (C-5) lithiation/iodination of the O,O-bis(triisopropylsilyl)resorcinoltricarbonylchrhomium(0) complex. The method was applied to the synthesis of moracin M (I).

Tetrahedron published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Safety of 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem