Preparation of α-aminophosphines on solid support: model studies and parallel synthesis was written by Bar-Nir Ben-Aroya, B.;Portnoy, Moshe. And the article was included in Tetrahedron in 2002.Formula: C10H8O3 This article mentions the following:
On-resin assembly of phosphine ligands represents a formidable challenge. Following model solution studies, the authors developed two synthetic routes for α-aminophosphine synthesis on solid support. The ligands were prepared via the Mannich reaction of the resin-bound aldehyde, amine and diphenylphosphine with very good yield and purity. Alternatively, the amine can serve as the anchoring building block. The ligands were qual. and quant. analyzed using gel-phase 31P and 13C NMR techniques. The studies culminated in the parallel synthesis of a 40-member library of borane-protected α-aminophosphines. For example, use of 4-formylbenzoic acid and 2-methylaniline gave 100% resin-bound -CH2O2CC6H4CH(NHC6H4Me-o)PPh2-p·BH3. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Formula: C10H8O3).
Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Formula: C10H8O3
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem