In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Identification of peptide fragments chemically cross-linked in cytochrome c oxidase from thermophilic Bacillus PS3, published in 1996-02-29, which mentions a compound: 70539-42-3, mainly applied to Bacillus cytochrome c oxidase structure crosslinking; protein quaternary domain structure crosslinking method, Category: benzofurans.
In order to study steric arrangement of subunits in cytochrome c oxidase isolated from thermophilic Bacillus PS3, we developed a simple procedure including chem. crosslinking, two consecutive runs of electrophoresis, proteolytic digestion, and peptide sequencing for simultaneous identification of two cross-linked fragments. By this procedure, the cytochrome c domain of subunit 2 was found cross-linked to the C-terminal region of subunit 1 including two hydrophobic transmembrane segments, suggesting that these two regions were located close each other. The present simple procedure might be applicable to proteins whose crystal structures are not revealed.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem