23-Sep-2021 News Properties and Exciting Facts About 57319-65-0

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 6-Aminoisobenzofuran-1(3H)-one, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 57319-65-0, Name is 6-Aminoisobenzofuran-1(3H)-one, molecular formula is C8H7NO2

Several conformationally restricted derivatives of (S)-3-bromo-N-((1- ethyl-2-pyrrolidinyl)methyl)-2,6-dimethoxybenzamide (remoxipride) were synthesized and evaluated in vitro for their ability to inhibit [3H]raclopride binding at the dopamine D-2 receptor. The cyclic benzamides designed to mimic the intramolecular hydrogen bonding of desmethylremoxipride (4, FLA-797) included 2,3-dihydro-4H-1,3-benzoxazin-4-ones, 2,3-dihydro-4H- 1,3-benzthiazin-4-ones, phthalimides, 1-isoindolinones, 1,2-benzisothiazol- 3(2H)-ones, and 1,2-benzisothiazol-3(2H)-one 1,1-dioxides. In this series, enhanced affinities to the dopamine D-2 receptor were not observed. The phthalimidine analogue 24b ((S)-6-chloro-2-(1-ethylpyrrolidinyl)-1- isoindolinone) exhibited the highest affinity to the dopamine D-2 receptor with an IC50 of 1.3 muM, which was equipotent to remoxipride.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1404O – PubChem