With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.
652-39-1, The best result occurs when the starting material is run 0.5 M in formamide and heated to 125 ¡ãC for 1 to 5 h depending on scale. Starting material is not soluble in fonnamide until the temperature is > 60 ¡ãC. Upon completion of reaction as monitored by LC/MS (apcineg), the heat is removed and 3 times the volume of the reaction of water is added. Next, the reaction is allowed to warm to room temperature and stirred until a pale yellow precipitate has formed. The yellow solid product is filtered off and washed with water before drying overnight to give yields between 70-77 percent.
As the paragraph descriping shows that 652-39-1 is playing an increasingly important role.
Reference£º
Patent; INTERMUNE, INC.; ARRAY BIOPHARMA INC.; WO2005/37214; (2005); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem