Heterocyclic Building Block-benzofuran

In vitro and in vivo MRI imaging and photothermal therapeutic properties of hematite nanorods was written by Gulzar, Aanisa;Ayoub, Nowsheena;Mir, Jaffar Farooq;Alanazi, Amer M.;Shah, M. A.;Gulzar, Arif. And the article was included in Journal of Materials Science: Materials in Medicine in 2022.Quality Control of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Herein we report synthesis of hematite (α-Fe₂O₃) nanorods by calcinating hydrothermally synthesized goethite nanorods at 5000C. The structural, optical and MRI imaging guided cancer therapeutic properties of fabricated nanorods have been discussed in this manscript. FESEM and TEM imaging techniques were used to confirm the nanorod like morphol. of as prepared materials. As we know that Fe₂O₃ nanorods with size in the range of 25-30 nm exhibit super magnetism. After coating with the PEG, the as prepared nanorods can be used as T2 MR imaging contrast agents. An excellent T2 MRI contrast of 38.763 mM-1s-1 achieved which is highest reported so far for α-Fe₂O₃. Besides the as prepared nanorods display an excellent photothermal conversion efficiency of 39.5% thus acts as an excellent photothermal therapeutic agent. Thus, we envision the idea of testing our nanorods for photothermal therapy and MR imaging application both in vitro and in vivo, achieving an excellent T2 MRI contrast and photothermal therapy effect with as prepared PEGylated nanorods. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Quality Control of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Quality Control of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Fluorescence determination of acrylamide in heat-processed foods was written by Liu, Congcong;Luo, Feng;Chen, Dongmei;Qiu, Bin;Tang, Xinhua;Ke, Huixian;Chen, Xi. And the article was included in Talanta in 2014.Application of 38183-12-9 This article mentions the following:

A simple and rapid fluorescence method has been developed for the determination of acrylamide in heat-processed food samples. In the determination, acrylamide is degraded through Hofmann reaction to generate vinyl amine, and pyrrolinone is produced when the vinyl amine reacts with fluorescamine, resulting in a strong fluorescence emission at 480 nm. Hofmann reaction is a key step for the fluorescence determination of acrylamide, and the reaction conditions are investigated and optimized. Under the optimal conditions, the fluorescence intensity increases with the increase of acrylamide concentrations The linear range between the fluorescence intensity and the square-root of acrylamide concentrations is from 0.05 μg mL^-1 to 20 μg mL^-1 with the correlation coefficient R²=0.9935. The detection limit is 0.015 μg mL^-1 and the recovery for food samples is from 66.0% to 110.6%. In comparison with Specification of Entry&Exit Inspection and Quarantine Bureau of The People’s Republic of China (SN/T 2281-2009), the method showed comparable results and demonstrated the accuracy of the method. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Application of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Application of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A visible-light responsive metal-organic framework as an eco-friendly photocatalyst under ambient air at room temperature was written by Liu, Yanhong;Lin, Chen;Li, Bowen;Wang, Jian;Wang, Man;Zhang, Na;Feng, Yue;Wu, Pengyan. And the article was included in Inorganic Chemistry Frontiers in 2020.Reference of 76-54-0 This article mentions the following:

Metal-organic frameworks (MOFs) have recently emerged as a new class of photocatalysts. However, most of these systems suffer from poor visible-light utilization, high cost, and low activity, and photocatalytically active MOFs in the visible-light spectral region are still relatively rare. Herein, a simple and effective strategy was developed to immobilize 2′,7′-dichlorofluorescein inside a porous metal-organic framework (MOF) for the first time. The MOF was applied as the first example of a visible-light responsive MOF-based catalyst for straightforward synthesis of 1,3-oxathiolane-2-imines from styrenes and ammonium thiocyanate under ambient air at room temperature, exhibiting good reusability, and the product can be scaled up to the gram level. The catalytic mechanism was also discussed. The approach reported in this study could open a new avenue in developing novel porous functional materials for a broad scope of visible-light-driven applications. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Reference of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Reference of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Natural peptide anti-glycation effect in the presence of Aloe vera phenolic components on human serum albumin was written by Moosavi-Movahedi, Ali Akbar;Ghamari, Fatemeh;Ghaffari, Seyed Mahmoud;Salami, Maryam;Farivar, Farzaneh;Moosavi-Movahedi, Faezeh;Johari, Anahita;Aminin, Agustina L. N.. And the article was included in RSC Advances in 2015.COA of Formula: C17H10O4 This article mentions the following:

The Maillard reaction, non-enzymic glycation after a complex series of reactions that involve reducing-sugars and proteins, produces a large number of end-products that are known as advanced glycation end-products (AGEs). AGEs are related to the pathogenesis of many diseases such as diabetes, inflammatory arthritis and cataracts. Today there is an increasing demand for natural AGE inhibitors for curing diabetes that have fewer side effects compared to synthetic drugs. The aim of this study was to explore the anti-glycation effect of aloin, in the presence and absence of casein-derived peptides, on human serum albumin (HSA). UV-visible and fluorescence spectroscopy were used to explore the number of free lysine residues, AGE formation and fibril formation during the HSA glycation. According to trinitrobenzenesulfonic acid and fluorescamine assay results, the presence of aloin and peptides reduced the number of glucose-attached lysine residues. Moreover AGE specific fluorescence and thioflavin T fluorescence decreased in the presence of aloin and peptides, indicative of a decrease in the formation of AGEs and fibrils resp. during the glycation of HSA. According to this study, aloin and camel casein derived peptides showed a synergic anti-glycation effect and inhibited the formation of fibrils and AGEs during the HSA glycation. This effect can be related to the antioxidant activity of aloin-peptide complex. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9COA of Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.COA of Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Development of ^99mTc-Labeled Pyridyl Benzofuran Derivatives To Detect Pancreatic Amylin in Islet Amyloid Model Mice was written by Yoshimura, Masashi;Ono, Masahiro;Watanabe, Hiroyuki;Kimura, Hiroyuki;Saji, Hideo. And the article was included in Bioconjugate Chemistry in 2016.Recommanded Product: (5-Methoxybenzofuran-2-yl)boronic acid This article mentions the following:

While islet amyloid deposition comprising amylin is one of pathol. hallmarks of type 2 diabetes mellitus (T2DM), no useful amylin-imaging probe has been reported. In this study, we evaluated two ^99mTc-labeled pyridyl benzofuran derivatives as novel amylin-imaging probes using the newly established islet amyloid model mouse. Binding experiments in vitro demonstrated that [^99mTc]1 displayed a higher affinity for amylin aggregates than [^99mTc]2. Autoradiog. studies using human pancreas sections with T2DM revealed that [^99mTc]1 clearly labeled islet amyloid in T2DM pancreatic sections, while [^99mTc]2 did not. Although the initial uptake of [^99mTc]1 by the normal mouse pancreas was low (0.74%ID/g at 2 min post-injection), [^99mTc]1 showed higher retention in the model mouse pancreas than that of the normal mouse, and exhibited strong binding to amylin aggregates in the living pancreas of the model mice. These results suggest that [^99mTc]1 is a potential imaging probe targeting islet amyloids in the T2DM pancreas. In the experiment, the researchers used many compounds, for example, (5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7Recommanded Product: (5-Methoxybenzofuran-2-yl)boronic acid).

(5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Recommanded Product: (5-Methoxybenzofuran-2-yl)boronic acid

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

PPh₃-assisted esterification of acyl fluorides with ethers via C(sp₃)-O bond cleavage accelerated by TBAT was written by Wang, Zhenhua;Wang, Xiu;Nishihara, Yasushi. And the article was included in Catalysts in 2019.Related Products of 1646-27-1 This article mentions the following:

The triphenylphosphine (PPh₃)-assisted methoxylation of acyl fluorides with cyclopentyl Me ether (CPME) accelerated by tetrabutylammonium difluorotriphenysilicate (TBAT) via regiospecific C-OMe bond cleavage was described. CPME was utilized not only as the solvent, but also as methoxylating agent. The reported method was featured by C-O and C-F bond cleavage under metal-free conditions, good functional-group tolerance and wide substrate scope. Mechanistic studies revealed that the radical process was not involved. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Related Products of 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Related Products of 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Spectrofluorimetric determination of aliskiren in dosage forms and urine was written by Aydogmus, Zeynep. And the article was included in Luminescence in 2012.Quality Control of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

A new, simple, and sensitive spectrofluorimetric method was developed for the determination of aliskiren (ALS) in dosage forms and human urine. The method is based on the reaction between ALS and fluorescamine in borate buffer solution, pH 9, to give a highly fluorescent derivative which is measured at 482 nm after excitation at 382 nm. The factors affecting the reaction were carefully studied. The fluorescence intensity concentration plots were rectilinear over the range 140-1400 ng/mL with a limit of detection 13.47 ng/mL and limit of quantitation 40.81 ng/mL. The developed method was successfully applied to the anal. of the drug in tablets and human urine; the average recoveries (n = 6) were 99.88 ± 0.38% and 99.57 ± 0.44%, resp. The anal. performance of the method was fully validated and the results were satisfactory. The stability of the drug was studied by subjecting it to acidic, basic, oxidative and thermal degradation Copyright © 2012 John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Quality Control of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Quality Control of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Labeling of nucleosides with fluorescamine and detection by spectrofluorometer for End Stage Renal Disease was written by Jamal, Shubi;Agrawal, Y. K.. And the article was included in Saudi Journal of Biological Sciences in 2013.Synthetic Route of C17H10O4 This article mentions the following:

Nucleosides are characterized as biomarkers in AIDS, Alzheimer, tumor, breast cancer and various malignant diseases. In the present work a direct method for the detection of nucleosides (adenosine, cytidine, uridine and guanosine) from urine samples has been developed. Nucleosides represent the extent of damage in genetic material, anal. of nucleosides by ultrasonic assisted microextraction effectively eliminates the interfering constituent of urine. This has made it a highly selective and sensitive method to analyze the nucleosides with a lower limit of detection 0.220 μmol/L and Limit of quantitation 0.660 μmol/L. The method has been validated with good linearity and correlation of coefficients of the calibration curves was higher than 0.997. The coefficients were in the range of 0.11-16.92% (inter-day) and 0.38-16.43% (intra-day), resp. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Synthetic Route of C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Synthetic Route of C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Continuous-Flow Synthesis of Perfluoroalkyl Ketones via Perfluoroalkylation of Esters Using HFC-23 and HFC-125 under a KHMDS-Triglyme System was written by Fujihira, Yamato;Iwasaki, Hiroto;Sumii, Yuji;Adachi, Hiroaki;Kagawa, Takumi;Shibata, Norio. And the article was included in Bulletin of the Chemical Society of Japan in 2022.Recommanded Product: 1646-27-1 This article mentions the following:

Herein, a method for the chem. transformation of two HFCs, viz was described. HFC-23 and HFC-125, based on the continuous-flow perfluoroalkylation of esters to synthesize the pharmaceutically and agrochem. vital trifluoromethyl and pentafluoroethyl ketones. The combination of a potassium base and a glyme solvent system was found to be the most effective. The proposed method was attractive for industrial use because it allows the consumption of a large volume of HFCs, promotes the synthesis of high-value medicinal compounds, and serves as an ideal alternative to the current HFC decomposition processes like thermal plasma treatment. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Recommanded Product: 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Recommanded Product: 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Methoxylation of Acyl Fluorides with Tris(2,4,6-trimethoxyphenyl)phosphine via C-OMe Bond Cleavage under Metal-Free Conditions was written by Wang, Xiu;Wang, Zhenhua;Ishida, Takumi;Nishihara, Yasushi. And the article was included in Journal of Organic Chemistry in 2020.Recommanded Product: Methyl benzofuran-2-carboxylate This article mentions the following:

Aryl fluorides (prepared from the corresponding aryl chlorides) underwent methoxylation reactions with tris(2,4,6-trimethoxyphenyl)phosphine (TMPP) (in the absence of added metal catalysts or reagents) in toluene to yield Me esters. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Recommanded Product: Methyl benzofuran-2-carboxylate).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Recommanded Product: Methyl benzofuran-2-carboxylate

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem