Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, SMILES is CC(NC1=CC=CC(C(O2)=O)=C1C2=O)=O, belongs to benzofurans compound. In a document, author is Hurtado, Diana Ximena, introduce the new discover, Formula: C10H7NO4.
Prostaglandins Isolated from the Octocoral Plexaura homomalla: In Silico and In Vitro Studies Against Different Enzymes of Cancer
Prostaglandin A(2)-AcMe (1) and Prostaglandin A(2) (2) were isolated from the octocoral Plexaura homomalla and three semisynthetic derivatives (3-5) were then obtained using a reduction protocol. All compounds were identified through one- and two-dimensional (1D and 2D) nuclear magnetic resonance (NMR) experiments. Additionally, evaluation of in vitro cytotoxic activity against the breast (MDA-MB-213) and lung (A549) cancer cell lines, in combination with enzymatic activity and molecular docking studies with the enzymes p38 alpha-kinase, Src-kinase, and topoisomerase II alpha, were carried out for compounds 1-5 in order to explore their potential as inhibitors of cancer-related molecular targets. Results showed that prostaglandin A(2) (2) was the most potent compound with an IC50 of 16.46 and 25.20 mu g/mL against MDA-MB-213 and A549 cell lines, respectively. In addition, this compound also inhibited p38 alpha-kinase in 49% and Src-kinase in 59% at 2.5 mu M, whereas topoisomerase II alpha was inhibited in 64% at 10 mu M. Enzymatic activity was found to be consistent with molecular docking simulations, since compound 2 also showed the lowest docking scores against the topoisomerase II alpha and Src-kinase (-8.7 and -8.9 kcal/mol, respectively). Thus, molecular docking led to establish some insights into the predicted binding modes. Results suggest that prostaglandin 2 can be considered as a potential lead for development inhibitors against some enzymes present in cancer processes.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 6296-53-3 is helpful to your research. Formula: C10H7NO4.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem