Total synthesis and stereochemical assignment of Nostosin B was written by Wang, Xiaoji;Feng, Junmin;Xu, Zhengshuang;Ye, Tao;Meng, Yi;Zhang, Zhiyu. And the article was included in Marine Drugs in 2017.Application of 200115-86-2 This article mentions the following:
Nostosins A and B were isolated from a hydrophilic extract of Nostoc sp. strain from Iran, which exhibits excellent trypsin inhibitory activity. Nostosin A was the most potent natural tripeptide aldehyde as trypsin inhibitor up to now. Both R- and S-2-hydroxy-4-(4-hydroxy-phenyl)butanoic acid (Hhpba) were prepared and incorporated into the total synthesis of nostosin B, resp. Careful comparison of the NMR spectra and optical rotation data of syntheticnostosin B (two isomers) with the natural product led to the unambiguous identification of the R-configuration of the Hhpba fragment, which was further confirmed by co-injection with the authentic sample on HPLC using both reversed phase column and the chiral AD-RH column. In the experiment, the researchers used many compounds, for example, H-Arg(Pbf)-OH (cas: 200115-86-2Application of 200115-86-2).
H-Arg(Pbf)-OH (cas: 200115-86-2) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Application of 200115-86-2
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem