Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, HPLC of Formula: C10H7NO4, 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, SMILES is CC(NC1=CC=CC(C(O2)=O)=C1C2=O)=O, belongs to benzofurans compound. In a document, author is Huang, Hao, introduce the new discover.
Discovery of novel benzofuran scaffold as 4-hydroxyphenylpyruvate dioxygenase inhibitors
BACKGROUND 4-Hydroxyphenylpyruvate dioxygenase (HPPD) plays an important role in addressing the issue of plant protection research. This study sheds new light on the differences in molecular scaffold from commercialized HPPD inhibitors. RESULTS The compounds A1-A18 and B1-B27 were synthesized for in vitro and greenhouse experiments. The greenhouse experiment data indicated that compounds B14 and B18 displayed excellent herbicidal activity, which was higher compared to that of mesotrione. In vitro testing indicated that the compounds were HPPD inhibitors. Moreover, molecular simulation results show that the compounds B14, B18, and mesotrione shared similar interplay with surrounding residues, which led to a perfect interaction with the active site of Arabidopsis thaliana HPPD. Based on crop selectivity results, compounds B14 and B18 were selected for maize studies (injury <= 10%), indicating its potential for weed control in maize fields. CONCLUSION These results showed that the pyrazole-benzofuran structure could be used as possible lead compounds for the development of HPPD inhibitors. A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 6296-53-3. HPLC of Formula: C10H7NO4.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem