One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Product Details of 42933-43-7, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 42933-43-7, Name is 2,3-Dihydrobenzofuran-5-amine, molecular formula is C8H9NO
A high throughput screening (HTS) hit, 1 (Plk1 Ki = 2.2 muM) was optimized and evaluated for the enzymatic inhibition of Plk-1 kinase. Molecular modeling suggested the importance of adding a hydrophobic aromatic amine side chain in order to improve the potency by a classic kinase H-donor-acceptor binding mode. Extensive SAR studies led to the discovery of 49 (Plk1 Ki = 5 nM; EC50 = 1.05 muM), which demonstrated moderate efficacy at 100 mpk in a MiaPaCa tumor model, with no overt toxicity.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Product Details of 42933-43-7, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 42933-43-7, in my other articles.
Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H515O – PubChem