Pan, Yu-Liang published the artcileEnantioselective Allylation of Oxocarbenium Ions Catalyzed by Bi(OAc)3/Chiral Phosphoric Acid, Quality Control of 52010-22-7, the main research area is alkenylborate hydroxyisobenzofuranone allylation bismuth chiral phosphoric acid; allylisobenzofuranone enantioselective preparation; bismuth chiral phosphoric acid enantioselective allylation catalyst.
Phthalides as the crucial core skeletons are found extensively in natural products and biol. active mols. Disclosed an asym. allylation of 3-hydroxyisobenzofuran-1(3H)-ones with boron allylation reagents to construct chiral phthalide derivatives The simple Bi(OAc)3/chiral phosphoric acid catalytic system proves to be efficient in this method, delivering the desired chiral 3-allylisobenzofuran-1(3H)-ones in good yields (up to 99%) and high enantioselectivities (up to 99.5:0.5 e.r.) under mild conditions. The large-scale reaction and diverse transformations of products to various scaffolds with potential biol. activities render it more attractive. Moreover, the mechanism was preliminarily explored by control reactions, mass spectrometry, deuterium experiment, and DFT calculations
ACS Catalysis published new progress about Allylation. 52010-22-7 belongs to class benzofurans, name is 4-Chlorophthalide, and the molecular formula is C8H5ClO2, Quality Control of 52010-22-7.
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem