Reference of 54450-20-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.54450-20-3, Name is 5-Bromobenzofuran-3(2H)-one, molecular formula is C8H5BrO2. In a Article，once mentioned of 54450-20-3
Three sets of antibacterial nitrofuran derivatives [set I, 5-R-substituted (Z)-2-(5-nitrofuran-2-ylmethylene)-3(2H)-benzofuranones (R = OCH3, H, CH3, C2H5, nC3H7, Cl, Br, CN, and NO2) and their 2-hydroxyphenyl and 2-acetoxyphenyl analogues; set TT, 5-R-substituted (E)-1-(2-hydroxyphenyl)-3-(5-nitrofuryl)-2-propen-1-ones (R = H, CH3, C2H5, Cl, and NO2); and set III, 5-R-substituted (E)-l-(2-acetoxyphenyl)-3-(5-nitrofuryl)-2-propen-l-ones (R = H, CH3; C2H5, Cl, and NO2)] were prepared and tested against a Gram-positive (Staphylococcus aureus, strain ATCC-25923) and a Gram-negative bacterium (Caulobacter crescentus, strain NA 1000). QSAR equations derived for the IC50 values against both bacteria show negative contributions of two terms: An electronic one, expressed either by sigma, the Hammett substituent constant, or by E, the cyclic voltametric reduction potential. Another term described by an indicator variable, Iabs, is assigned the value of 0 for set I compounds and the value of 1 for sets II and III. No important contribution of the hydrophobic factor was found. For the three sets, the QSAR regressions suggest that the same structural features describe the activities for both bacteria and that, although reduction is a necessary step, it should not be the determining one. These results agree with those found for the QSAR of 5-nitroimidazole analogues.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 54450-20-3, and how the biochemistry of the body works.Reference of 54450-20-3
Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3618O – PubChem