57319-65-0, Name is 6-Aminoisobenzofuran-1(3H)-one, belongs to benzofurans compound, is a common compound. COA of Formula: C8H7NO2In an article, once mentioned the new application about 57319-65-0.
SHP2 is a new promising target for anti-cancer drug discovery. A series of novel phenylhydrazonopyrazolone derivatives was synthesized by a more convenient method, and their chemical structures were characterized by various spectroscopic methods. The inhibitory effects of these compounds on SHP2 enzyme and SHP2-dependent cancer cell H1975 were evaluated. The compound 11f with IC50 value of 3.38 mumol/L exhibited more potent antitumor activity against H1975 cell than GS-493 (IC50 = 20.92 mumol/L). Molecular dynamics simulation of compound 11f displayed a possible mode of interaction between this compound and SHP2 enzyme.
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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1389O – PubChem