With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.77095-51-3,Benzofuran-6-carboxylic acid,as a common compound, the synthetic route is as follows.
77095-51-3, 16.05 g (0.10 mol) of benzofuran-6-carboxylic acid (compound III) were added over a suspension of 16.05 g (0.10 mol) of 1 ,T-carbonyldiimidazole in 400 mL of ethyl acetate at 20-25 C, under nitrogen atmosphere. The mixture was stirred at 20-25 C for 1 hour, and the resulting solution was added over a mixture of 53.8 g (0.09 mol) of crude hydrochloride salt of benzyl (S)-2-(5,7-dichloro-1 ,2,3,4-tetrahydroisoquinoline-6- carboxamido)-3-[3-(methylsulfonyl)phenyl]propanoate (compound IV) as obtained in Example 1 and 37.6 ml. (0.22 mol) of /V,/V-diisopropylethylamine in a mixture of 200 ml. of ethyl acetate and 55 ml. of dimethylsulfoxide at 20-25 C. The resulting mixture was stirred at this temperature for 18 hours. 1.05 L of 0.5 M hydrochloric acid and 500 ml. of ethyl acetate were added. The organic phase was extracted, washed with 2 x 500 ml. of 4% (w/w) aqueous sodium bicarbonate and with 500 ml. of deionized water, in sequence. The organic layer was concentrated to dryness under reduced pressure, to give 63.1 g of benzyl (S)-2-[2-(benzofuran-6-carbonyl)-5,7-dichloro-1 ,2,3,4-tetrahydroisoquinoline-6- carboxamido]-3-[3-(methylsulfonyl)phenyl]propanoate (compound II) as a yellowish solid.
As the paragraph descriping shows that 77095-51-3 is playing an increasingly important role.
Reference£º
Patent; MEDICHEM, S.A.; BIN, Zhu; LINGXIANG, Rao; PUIG SERRANO, Jordi; DURAN LOPEZ, Ernesto; (28 pag.)WO2019/96996; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem