Visible-Light Photoredox-Catalyzed Carboxylation of Activated C(sp3)-O Bonds with CO2 was written by Ran, Chuan-Kun;Niu, Ya-Nan;Song, Lei;Wei, Ming-Kai;Cao, Yi-Fei;Luo, Shu-Ping;Yu, Yu-Ming;Liao, Li-Li;Yu, Da-Gang. And the article was included in ACS Catalysis in 2022.Category: benzofurans This article mentions the following:
A visible-light photoredox-catalyzed carboxylation of activated C(sp3)-O bonds with CO2 under mild and transition-metal-free conditions was reported. A variety of benzyl alcs. and derivatives, RCH(R1)OR2 (R = 4-phenylphenyl, 6-methoxynaphthalen-2-yl, 1-benzofuran-2-yl, etc.; R1 = H, Me, cyclohexyl, propan-2-yl, etc.; R2 = H, Piv, Ac) bearing primary, secondary, and more challenging tertiary C(sp3)-O bonds, undergo carboxylation with CO2, generating valuable aryl acetic acids RCH(R1)COOH, such as ibuprofen, naproxen, fenoprofen, and flurbiprofen, with broad substrate scope and good functional group tolerance. Moreover, this strategy is also applicable to other carboxylates of α-hydroxyl amides, esters, and nitriles, as well as allyl alcs., representing a practical method for aliphatic carboxylic acid synthesis. In the experiment, the researchers used many compounds, for example, 2-Benzofuranacetic acid (cas: 62119-70-4Category: benzofurans).
2-Benzofuranacetic acid (cas: 62119-70-4) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Category: benzofurans
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem