Properties and Exciting Facts About C4H4O2

Electric Literature of 497-23-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 497-23-4.

Electric Literature of 497-23-4, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, belongs to benzofurans compound. In a article, author is Gao, Feng, introduce new discover of the category.

Benzofuran-isatin hybrids and their in vitro anti-mycobacterial activities against multi-drug resistant Mycobacterium tuberculosis

A series of benzofuran-isatin hybrids 6a-n and 7a-g linked by alkyl linkers were designed and synthesized. Among them, hybrids 6a-1 and 7a-g were assessed for their in vitro anti-mycobacterial activities against two multi-drug resistant Mycobacterium tuberculosis (MDR-MTB) strains and the cytotoxicity towards CHO cells. The preliminary results indicated that all hybrids (MIC: 0.125-16 mu g/mL) showed excellent activity against the tested MDR-MTB strains, and low cytotoxicity (CC50: 64->512 mu g/mL) towards CHO cells. Among them, hybrid 7e (MIC: 0.125 and 0.25 mu g/mL) was highly active against the tested two MDR-MTB strains, which was 8-16 folds better than ciprofloxacin (MIC: 1 and 4 mu g/mL), >= 512 folds more potent than rifampicin (MIC: 64 and > 128 mu g/mL) and isoniazid (MIC: >128 mu g/mL), but it was less active than TAM16 (MIC: <0.06 mu g/mL). Moreover, the hybrid 7e (CC50: 128 mu g/mL) also showed low cytotoxicity towards CHO cells, and high selectivity index (1,024). However, the metabolic stability and in vivo pharmacokinetic profiles of hybrid 7e were inferior to TAM16, so it still needs to be modified so as to get the optimized hybrid for potential use in mycobacterial treatment. (C) 2019 Elsevier Masson SAS. All rights reserved. Electric Literature of 497-23-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 497-23-4.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem