Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 174775-48-5, Name is Ethyl 5-aminobenzofuran-2-carboxylate, molecular formula is C11H11NO3, belongs to benzofurans compound. In a document, author is Doonaboyina, Raghava, introduce the new discover, Application In Synthesis of Ethyl 5-aminobenzofuran-2-carboxylate.
SYNTHESIS OF NOVEL 2-PHENYL-1-BENZOFURAN-3(2H)-ONE DERIVATIVES AS NEW LEADS FOR ANTI-CANCER ACTIVITY
Benzofuranone is a bicyclic ring where a benzene ring fused with a furanone. Synthetic chemistry plays a major in developing a series of potent anti-cancer agents. Bromophenyl acetonitrile was prepared from phenyl acetonitrile by bromination at an alpha position which yielded bromophenyl acetonitrile which was a lachrymator compound. Benzofuranone was synthesized by reacting benzene diols and triols with bromo phenyl acetonitrile yielded an imine derivative are converted to a ketone with treatment with hydrochloric acid then cyclized with sodium acetate. The compounds identity and purity are confirmed by spectral and analytical methods. Benzofuranone derivatives are screened anti-neoplastic activity was performed against human skin cancer cell line G361 at micro molecular concentrations. The compounds IA. IB, ID, IE, IF, IIB, IIC, IIIA, IVB, IVF, VA. VC, VD, VE was found to be with potent activity. These compounds exhibited an excellent activity while compared to reference standard doxorubicin at different micromolar concentrations as such of the synthesized compounds.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 174775-48-5. Application In Synthesis of Ethyl 5-aminobenzofuran-2-carboxylate.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem