So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Yohda, Masaaki; Yamamoto, Yasunori researched the compound: Methyl 4-bromo-2-formylbenzoate( cas:1260795-42-3 ).COA of Formula: C9H7BrO3.They published the article 《Enantioselective addition of arylboronic acids to methyl 2-formylbenzoates by using a ruthenium/Me-BIPAM catalyst for synthesis of chiral 3-aryl-isobenzofuranones》 about this compound( cas:1260795-42-3 ) in Organic & Biomolecular Chemistry. Keywords: boronic acid formyl benzoate addition ruthenium bidentate phosphoramidite catalyst; isobenzofuranone aryl preparation enantioselective. We’ll tell you more about this compound (cas:1260795-42-3).
A series of chiral 3-aryl-isobenzofuranones I (R = 5-CF3, 6-Br, 7-CH3, etc.; Ar = Ph, 2-naphthyl, 3-thienyl, etc.) were synthesized via ruthenium/Me-BIPAM-catalyzed asym. addition of arylboronic acids ArB(OH)2 to Me 2-formylbenzoates R1C(O)H [R1 = 2-C(O)OCH3-C6H4, 2-C(O)OCH3-5-CF3-C6H3, 2-C(O)OCH3-4-Cl-C6H3, etc.]. The [RuCl2 (p-cymene)]2/Me-BIPAM and RuCl2(PPh3)3/Me-BIPAM catalyst systems tolerate a variety of functional groups and give high yields with high enantioselectivities.
As far as I know, this compound(1260795-42-3)COA of Formula: C9H7BrO3 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem