Related Products of 54802-10-7, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 54802-10-7, Name is 3-Aminobenzofuran-2-carboxamide, molecular formula is C9H8N2O2. In a Article£¬once mentioned of 54802-10-7
Discovery of XL413, a potent and selective CDC7 inhibitor
CDC7 is a serine/threonine kinase that has been shown to be required for the initiation and maintenance of DNA replication. Up-regulation of CDC7 is detected in multiple tumor cell lines, with inhibition of CDC7 resulting in cell cycle arrest. In this paper, we disclose the discovery of a potent and selective CDC7 inhibitor, XL413 (14), which was advanced into Phase 1 clinical trials. Starting from advanced lead 3, described in a preceding communication, we optimized the CDC7 potency and selectivity to demonstrate in vitro CDC7 dependent cell cycle arrest and in vivo tumor growth inhibition in a Colo-205 xenograft model.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Related Products of 54802-10-7. In my other articles, you can also check out more blogs about 54802-10-7
Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H2827O – PubChem