Chromatography columns packed with thermoresponsive-cationic-polymer-modified beads for therapeutic drug monitoring was written by Nagase, Kenichi;Takagi, Hikaru;Nakada, Hideo;Ishikawa, Haruki;Nagata, Yoshiko;Aomori, Tohru;Kanazawa, Hideko. And the article was included in Scientific Reports in 2022.COA of Formula: C17H20O6 This article mentions the following:
Therapeutic drug monitoring, which is used to determine appropriate drug doses, is critical in pharmacol. therapy. In this study, we developed thermoresponsive chromatog. columns with various cationic properties for effective therapeutic drug monitoring. Thermoresponsive cationic copolymer poly(N-isopropylacrylamide-co-Bu methacrylate-co-N,N-dimethylaminopropyl acrylamide) (P(NIPAAm-co-BMA-co-DMAPAAm))-modified silica beads, which were used as the chromatog. stationary phase, were prepared by modifying the radical initiator of the silica beads, followed by radical polymerization Characterization of the prepared silica beads demonstrated that thermoresponsive polymers with various cationic properties successfully modified the beads. The elution behavior of several steroids in the prepared bead-packed columns at various temperatures indicated that the optimal column operating temperature was 30 °C. Appropriate measurement conditions for 13 drugs were investigated by varying the cationic properties of the columns and the pH of the mobile phase. Drug concentrations in serum samples were determined using the developed columns and mobile phases with a suitable pH. Voriconazole concentrations in human serum samples were determined using the developed columns with all-aqueous mobile phases. We anticipate that the developed chromatog. columns can be used for therapeutic drug monitoring because drug concentrations can be measured using all-aqueous mobile phases that are suitable in clin. settings. In the experiment, the researchers used many compounds, for example, (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1COA of Formula: C17H20O6).
(E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.COA of Formula: C17H20O6
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem