More research is needed about Isobenzofuran-1(3H)-one

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Otvos, SB; Kappe, CO or concate me.. COA of Formula: C8H6O2

An article Continuous-Flow Amide and Ester Reductions Using Neat Borane Dimethylsulfide Complex WOS:000514466200001 published article about DIBAL-H REDUCTION; CATALYTIC-HYDROGENATION; CARBONYL REDUCTIONS; CHEMISTRY; GREEN; EFFICIENT; CINACALCET; TOOLS in [Oetvoes, Sandor B.; Kappe, C. Oliver] Karl Franzens Univ Graz, Inst Chem, NAWI Graz, Heinrichstr 28, A-8010 Graz, Austria; [Kappe, C. Oliver] RCPE, Ctr Continuous Synth & Proc CCFLOW, Inffeldgasse 13, A-8010 Graz, Austria in 2020, Cited 63. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. COA of Formula: C8H6O2

Reductions of amides and esters are of critical importance in synthetic chemistry, and there are numerous protocols for executing these transformations employing traditional batch conditions. Notably, strategies based on flow chemistry, especially for amide reductions, are much less explored. Herein, a simple process was developed in which neat borane dimethylsulfide complex (BH3 center dot DMS) was used to reduce various esters and amides under continuous-flow conditions. Taking advantage of the solvent-free nature of the commercially available borane reagent, high substrate concentrations were realized, allowing outstanding productivity and a significant reduction in E-factors. In addition, with carefully optimized short residence times, the corresponding alcohols and amines were obtained in high selectivity and high yields. The synthetic utility of the inexpensive and easily implemented flow protocol was further corroborated by multigram-scale syntheses of pharmaceutically relevant products. Owing to its beneficial features, including low solvent and reducing agent consumption, high selectivity, simplicity, and inherent scalability, the present process demonstrates fewer environmental concerns than most typical batch reductions using metal hydrides as reducing agents.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Otvos, SB; Kappe, CO or concate me.. COA of Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem