Little discovery in the laboratory: a new route for 90866-33-4

This literature about this compound(90866-33-4)Computed Properties of C6H11ClO3has given us a lot of inspiration, and I hope that the research on this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate) can be further advanced. Maybe we can get more compounds in a similar way.

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 90866-33-4, is researched, SMILESS is O=C(OCC)C[C@@H](O)CCl, Molecular C6H11ClO3Journal, Evaluation Study, Article, Research Support, Non-U.S. Gov’t, Journal of Industrial Microbiology & Biotechnology called Bioconversion of ethyl 4-chloro-3-oxobutanoate by permeabilized fresh brewer’s yeast cells in the presence of allyl bromide, Author is Yu, Ming-An; Wei, Yu-Meng; Zhao, Ling; Jiang, Lan; Zhu, Xiao-bing; Qi, Wei, the main research direction is brewers yeast reduction permeabilized.Computed Properties of C6H11ClO3.

Ethyl(R)-4-chloro-3-hydroxybutanoate ((R)-CHBE) was obtained by cetyltrimetylammonium bromide (CTAB) permeabilized fresh brewer’s yeast whole cells bioconversion of Et 4-chloro-3-oxobutanoate (COBE ) in the presence of allyl bromide. The results showed that the activities of alc. dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in CTAB permeabilized brewer’s yeast cells increased 525 and 7.9-fold, resp., compared with that in the nonpermeabilized cells and had high enantioselectivity to convert COBE to (R)-CHBE. As one of co-substrates, glucose-6-phosphate was preprepared using glucose phosphorylation by hexokinase-catalyzed of CTAB permeabilized brewer’s yeast cells. In a two phase reaction system with Bu acetate as organic solvent and with 2-propanol and glucose-6-phosphate as co-substrates, the highest (R)-CHBE concentration of 447 mM was obtained with 110-130 g/l of the CTAB permeabilized cells at optimized pH, temperature, feeding rate and the shake speed of 125 r/min. The yield and enantiomeric excess (ee) of (R)-CHBE reached 99.5 and 99%, resp., within 6 h.

This literature about this compound(90866-33-4)Computed Properties of C6H11ClO3has given us a lot of inspiration, and I hope that the research on this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem