Chemo- and Site-Selective Fischer Esterification Catalyzed by B(C6F5)3 was written by Li, Ya-Lan;Pang, Jin-Yu;Lou, Ji-Cong;Sun, Wen-Wu;Liu, Ji-Kai;Wu, Bin. And the article was included in Asian Journal of Organic Chemistry in 2021.Application In Synthesis of 2-Benzofuranacetic acid This article mentions the following:
A direct and catalytic dehydrative esterification of carboxylic acids RC(O)OH [R = hept-1-yn-1-yl, 2-(naphthalen-2-yl)ethyl, (1-methyl-1H-indol-3-yl)methyl, 1-([(benzyloxy)carbonyl]amino)ethyl, etc.] with alcs. R1OH (R1 = Et, cyclohexyl, 2,3-dihydroxypropyl, etc.) is described. B(C6F5)3 is shown to be a highly effective catalyst for the Fischer esterification, providing esters RC(O)OR1 in high to excellent yields. This esterification shows excellent chemo- and site-selective monoesterification of various polyols R1OH without any protection step, including bio-derived mol. glycerol. In the experiment, the researchers used many compounds, for example, 2-Benzofuranacetic acid (cas: 62119-70-4Application In Synthesis of 2-Benzofuranacetic acid).
2-Benzofuranacetic acid (cas: 62119-70-4) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Application In Synthesis of 2-Benzofuranacetic acid
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem