Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: Benzo[b]furan-2-carboxaldehyde, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 4265-16-1
Asymmetric synthesis and bioselective activities of alpha-amino-phosphonates based on the dufulin motif
The asymmetric synthesis of enantiomerically pure alpha-aminophosphonates with high and bioselective activities is a challenge. Here, we report that both enantiomers of alpha-aminophosphonates bearing the N-benzothiazole moiety can be prepared in high yields (up to 99%) and excellent enantioselectivities (up to 99% ee) by using chiral thiourea organocatalysts. Evaluation of the antiviral activities of our reaction products against cucumber mosaic virus (CMV) led to promising hits with high and selective biological activities, wherein (R)-enantiomers exhibit higher biological activities than the corresponding (S)-enantiomers. Especially, compound (R)-3b with excellent anti-CMV activity (curative activity, 72.3%; protection activity, 56.9%; and inactivation activity, 96.9%) at 500 mug/mL emerged as a potential inhibitor of the plant virus. The difference in the selective bioactivity could be affected by the combination mode of the three-dimensional space between the enantiomers of alpha-aminophosphonate and cucumber mosaic virus coat protein (CMV-CP) via florescence spectroscopy and molecular docking.
If you are interested in 4265-16-1, you can contact me at any time and look forward to more communication. Recommanded Product: Benzo[b]furan-2-carboxaldehyde
Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H1130O – PubChem