Application of 66357-35-5, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 66357-35-5, Name is Ranitidine, SMILES is O=[N+]([O-])/C=C(NCCSCC1=CC=C(O1)CN(C)C)NC, belongs to benzofurans compound. In a article, author is Ali, Irfan, introduce new discover of the category.
Potent alpha-amylase inhibitors and radical (DPPH and ABTS) scavengers based on benzofuran-2-yl(phenyl)methanone derivatives: Syntheses, in vitro, kinetics, and in silico studies
Thirty benzofuran-2-yl(phenyl)methanones 1-30 were synthesized and characterized their structures by spectroscopic techniques. Substituted phenacyl bromide and different derivatives of 2-hydroxy-benzaldehyde treated in the presence of anhydrous K2CO3 in acetonitrile at room temperature to afford the desired benzofurans 1-30. All compounds were screened for their in vitro alpha-amylase inhibitory and radical scavenging (DPPH and ABTS) activities. Results revealed that para substituted compounds were found to be more active than the others with IC50 values ranges for alpha-amylase inhibition (IC50 = 18.04-48.33 JIM), DPPH (IC50 = 16.04-32.33 JIM) and ABTS (IC50 = 16.99-33.01 JIM) radical scavenging activities. Activities results were compared with the standards acarbose (IC50 = 16.08 +/- 0.07 JIM) for alpha-amylase, ascorbic acid (IC50 = 15.08 +/- 0.03 and 15.09 +/- 0.17 JIM) for DPPH and ABTS radical scavenging activities, respectively. Kinetic studies predicted that all compounds followed non-competitive mechanism of inhibition. Molecular docking results showed good protein-ligand interactions profile against the corresponding target. To the best of our knowledge, out of thirty molecules, ten compounds 18-20, 22, and 25-30 were structurally new.
Application of 66357-35-5, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 66357-35-5 is helpful to your research.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem