Extended knowledge of 3-Methylbenzofuran-2-carboxylic acid

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(Matrix presented) A palladium-catalyzed decarboxylative arylation reaction was shown to produce Heck-type coupling products using a number of different arene carboxylic acid and 2-cycloalken-1-one substrates. The more conventional Heck coupling of an aryl iodide and a 2-cycloalken-1-one reactant was also briefly explored for comparison, where it was found that phosphine-free (Jeffery) conditions afforded the highest yield of product.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2778O – PubChem