Analyzing the synthesis route of 24673-56-1

The synthetic route of 24673-56-1 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24673-56-1,3-Methylbenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

3-methylbenzofuran-2-carboxylic acid (0.4 mmol, 1 equiv), bis(4-cyanophenyl) diselenide (0.8 mmol, 2 equiv), Cu(OAc) 2 (0.06) at room temperature (mmol), 1,10-phenanthroline (0.06 mmol), potassium carbonate (1.2 mmol, 3 equiv) and 2 mL of toluene were added to the reaction tube, which was then filled with oxygen and replaced three times in an oxygen reaction environment at 150C. The reaction temperature was stirred for 24 h. By the end of the reaction was monitored by thin layer chromatography, the reaction mixture was cooled, filtered and then ethyl acetate was added, and then spin off the solvent, the product obtained was isolated by column chromatography (eluent: petroleum ether: diethyl ether = 98), the product is Yellow liquid, yield 77%, product weight 96 mg., 24673-56-1

The synthetic route of 24673-56-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wenzhou Medical University; Wu Ge; Wang Jing; (14 pag.)CN107188846; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem