With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7168-85-6,7-Methoxybenzofuran,as a common compound, the synthetic route is as follows.
General procedure: Commercial 2-ethylfuran (1.9 g, 20 mmol, 1 eq) dissolved theanhydrous 15 mL THF, and the solution was added n-BuLi (10 mL, 2.5 M solution in hexane), The mixture wasstirred at 0 C for 3 h, then it was cannulated over 20 min into a solution of trimethyl borate (2.28 g, 22 mmol, 1.1eq) in 5 mL THF. The mixture was warmed to r.t., and cooled back to 0 C after stirring for 30 min. 1N aq. HCl(18 mL) was added to neutral pH, and extracted with ether. The combined extracts were washed with water anddried with Na2SO4 and concentrated to furnish the boric acid, 1.25 g. To the solution of (5-ethylfuran-2-yl)boronicacid (610 mg, 4.35 mmol, 1 eq) in 1.5 mL MeOH under N2 was added KHF2 (610 mg, 4.35 mmol, 1 eq) in oneportion at 0 C, To the suspension was added 3.8 mL H2O, then the ice-water bath was removed and the reactionwas stirred for 10 min. The crude mixture was concentrated and dried overnight in vacuo. The solid was extractedwith acetone for 3 times, and the crude solid was recrystallized with acetone/ether to yield the title compound (460mg, 23% over 2 steps)., 7168-85-6
The synthetic route of 7168-85-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Zheng, Hongbo; Li, Lin; Sun, Bin; Gao, Yun; Song, Wei; Zhao, Xiaoyu; Gao, Yanhui; Xie, Zhiyu; Zhang, Nianzhao; Ji, Jianbo; Yuan, Huiqing; Lou, Hongxiang; European Journal of Medicinal Chemistry; vol. 150; (2018); p. 30 – 38;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem