128851-73-0, 6-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 1) 6-bromo-3- (chloromethyl) benzofuran To a solution of 6-bromobenzofuran (484 mg, 2.27 mmol) in benzene (0.2 mL) were added aqueous formaldehyde (1 mL) and concentrated hydrochloric acid (1 mL) . The mixture was purged with HCl gas and heated at 70 for 1 hour. The mixture was diluted with EtOAc (40 mL) , and then washed with water (20 mL) and saturated aqueous NaCl, dried over anhydrous Na2SO4. The mixture was concentrated in vacuo. The residue was purified by silica gel column chromatography eluted with DCM to give 6-bromo-3- (chloromethyl) benzofuran as a white solid (490 mg, 82) .[1032]MS (ESI, pos. ion) m/z: 244.9 [M+H]+., 128851-73-0
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Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; XIE, Hongming; WU, Xiwei; REN, Qingyun; ZHANG, Jiancun; (236 pag.)WO2015/197028; (2015); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem