Brief introduction of 77095-51-3

77095-51-3 Benzofuran-6-carboxylic acid 17867234, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.77095-51-3,Benzofuran-6-carboxylic acid,as a common compound, the synthetic route is as follows.

An oven-dried flask was charged with 2 (40 mg, 0.103 mmol), EDC.HCl (29.5 mg, 0.154 mmol), DMAP (18.8 mg, 0.154 mmol), and the appropriate acid (0.154 mmol). To the flask was added CH2CI2 (8 mL). After stirring overnight at RT the reaction was quenched with HC1 (1 M, 8 mL) and the organic layer rinsed sequentially with saturated NaHCCh (8 mL) and brine (8 mL) then dried over NarSOu The solvent was removed in vacuo and the resulting residue purified by flash column chromatography (?FCC?) eluting with 30-35% EtOAc/Pent. Compounds <95% pure as indicated by HPLC were further purified by reverse phase semi -preparatory HPLC. 77095-51-3 Benzofuran-6-carboxylic acid 17867234, abenzofuran compound, is more and more widely used in various. Reference£º
Patent; UNIVERSITY OF KANSAS; VICTORIA LINK LIMITED; PRISINZANO, Thomas E.; CROWLEY, Rachel Saylor; DAKEN, Bronwyn Maree; (56 pag.)WO2019/99588; (2019); A1;,
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