Bouarfa, Salima’s team published research in Synthesis in 53 | CAS: 69626-75-1

Synthesis published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Name: 2-Iodobenzofuran.

Bouarfa, Salima published the artcileIodothiophenes and Related Compounds as Coupling Partners in Copper-Mediated N-Arylation of Anilines, Name: 2-Iodobenzofuran, the publication is Synthesis (2021), 53(7), 1271-1284, database is CAplus.

N-Arylation of various 2-acylated anilines 2-NH2-5-R-C6H3C(O)R1 (R = H, Cl; R1 = H, Me, Ph) with different electron-rich heteroaryl iodides R2I (R2 = thiophen-2-yl, 1-benzothiophen-3-yl, furan-2-yl, etc.) was achieved by using activated copper and potassium carbonate in di-Bu ether at reflux. The reactivity of the different heteroaryl iodides and anilines employed was discussed and rationalized on the basis of their electronic features. Subsequent cyclization by aromatic electrophilic substitution easily took place in the case of C2-free (benzo)thienyl I (X = O, S) or C3-free (benzo)furyl derivatives, II affording original tri- and tetracycles. The antiproliferative activity of most of them was evaluated in A2058 melanoma cells and revealed four chlorinated tetracycles as effective growth inhibitors.

Synthesis published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Name: 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem