Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is , belongs to benzofurans compound. In a document, author is Santi, Micol, Recommanded Product: N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide.
Metal-Free Tandem Rearrangement/Lactonization: Access to 3,3-Disubstituted Benzofuran-2-(3H)-ones
A novel metal-free synthesis of 3,3-disubstituted benzofuran-2-(3H)-ones through reacting alpha-aryl-alpha-diazoacetates with triarylboranes is presented. Initially, triarylboranes were successfully investigated in alpha-arylations of alpha-diazoacetates, however in the presence of a heteroatom in the ortho position, the boron enolate intermediate undergoes an intramolecular rearrangement to form a quaternary center. The intermediate cyclizes to afford valuable 3,3-disubstituted benzofuranones in good yields.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 6296-53-3, in my other articles. Recommanded Product: N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem