Chemistry is an experimental science, Computed Properties of C4H4O2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 497-23-4, Name is Furan-2(5H)-one, molecular formula is C4H4O2, belongs to benzofurans compound. In a document, author is Yin, Jiangliang.
Acyl radical to rhodacycle addition and cyclization relay to access butterfly flavylium fluorophores
Transition metal-catalyzed C-H activation and radical reactions are two versatile strategies to construct diverse organic skeletons. Here we show the construction of a class of flavylium fluorophores via the merge of radical chemistry and C-H activation starting from (hetero)aryl ketones and alkynes. This protocol is not only applicable to aryl ketones but also to heteroaryl ketones such as thiophene, benzothiophene and benzofuran, thus leading to structural diversity. Mechanism studies, including control experiments, intermediate separation, radical trapping, EPR and ESI-HRMS experiments, demonstrate that the key step lies in the addition of the acyl radical generated by the copper-catalyzed C-C bond cleavage of aryl ketone to the rhodacycle formed via the C-H activation of aryl ketone. The flavylium fluorophores feature butterfly symmetrical configuration, nearly planar skeleton and delocalized positive charge, and exhibit intriguing photophysical properties, such as tunable absorption and emission wavelengths and high quantum yields.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 497-23-4, in my other articles. Computed Properties of C4H4O2.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem