One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Product Details of 54450-20-3, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 54450-20-3, Name is 5-Bromobenzofuran-3(2H)-one, molecular formula is C8H5BrO2
Btk inhibitors and PI3Kdelta inhibitors play crucial roles in the treatment of leukemia, and studies confirmed that the synergetic inhibition against Btk and PI3Kdelta could gain an optimal response. Herein, a series of novel benzofuro[3,2-b]pyridin-2(1H)-one derivatives were designed and synthesized as dual Btk/PI3Kdelta kinases inhibitors for the treatment of leukemia. Studies indicated that most compounds could suppress the proliferation of multiple leukemia or lymphoma cells (Raji, HL60 and K562 cells) at low micromolar concentrations in vitro. Further kinase assays identified several compounds could simultaneously inhibit Btk kinase and PI3Kdelta kinase. Thereinto, compound 16b exhibited the best inhibitory activity (Btk: IC50 = 139 nM; PI3Kdelta: IC50 = 275 nM) and showed some selectivity against PI3Kdelta compared to PI3Kbeta/gamma. Finally, the SAR of target compounds was preliminarily discussed combined with docking results. In brief, 16b possessed of the potency for the further optimization as anti-leukemia drugs by inhibiting simultaneously Btk kinase and PI3Kdelta kinase.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Product Details of 54450-20-3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 54450-20-3, in my other articles.
Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3614O – PubChem