Month: December 2022

Zhong, Zhuoheng published the artcileMolecular characterization of a geranyl diphosphate-specific prenyltransferase catalyzing stilbenoid prenylation from Morus alba, Application In Synthesis of 56317-21-6, the publication is Plant and Cell Physiology (2018), 59(11), 2214-2227, database is CAplus and MEDLINE.

Pharmaceutically active compounds from medical plants are attractive as a major source for new drug development. Prenylated stilbenoids with increased lipophilicity are valuable secondary metabolites which possess a wide range of biol. activities. So far, many prenylated stilbenoids have been isolated from Morus alba but the enzyme responsible for the crucial prenyl modification remains unknown. In the present study, a stilbenoid-specific prenyltransferase (PT), termed Morus alba oxyresveratrol geranyltransferase (MaOGT), was identified and functionally characterized in vitro. MaOGT recognized oxyresveratrol and geranyl diphosphate (GPP) as natural substrates, and catalyzed oxyresveratrol prenylation. Our results indicated that MaOGT shared common features with other aromatic PTs, e.g. multiple transmembrane regions, conserved functional domains and targeting to plant plastids. This distinct PT represents the first stilbenoid-specific PT accepting GPP as a natural prenyl donor, and could help identify addnl. functionally varied PTs in moraceous plants. Furthermore, MaOGT might be applied for high-efficiency and large-scale prenylation of oxyresveratrol to produce bioactive compounds for potential therapeutic applications.

Plant and Cell Physiology published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C19H14O2, Application In Synthesis of 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Hu, Qiu-Fen published the artcileAntiviral Phenolic Compounds from Arundina graminifolia, Formula: C14H10O4, the publication is Journal of Natural Products (2013), 76(2), 292-296, database is CAplus and MEDLINE.

Five new phenolic compounds, gramniphenols C-G (I–V), and eight known compounds (6-13) were isolated from the whole plant of Arundina graminifolia. Compounds 1, 4, and 5 showed anti-tobacco mosaic virus activity, with IC₅₀ values of 20.8, 40.8, and 57.7 μM, resp. Compounds 1-10 were also tested for their anti-HIV-1 activity; compounds 2, 3, and 6 displayed anti-HIV-1 activity with therapeutic index values above 100:1.

Journal of Natural Products published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Formula: C14H10O4.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Cao, Yan-gang published the artcileTwo new phenolic constituents from the root bark of Morus alba L. and their cardioprotective activity, Related Products of benzofurans, the publication is Natural Product Research (2018), 32(4), 391-398, database is CAplus and MEDLINE.

A new biphenyl-furocoumarin, named morescoumarin A, and a new prenylated flavanone, named morflavanone A were isolated from the root bark of Morus alba L., together with four known compounds Their structures were determined by extensive spectroscopic analyses and comparison with literature data. The cardioprotective effects of these compounds against doxorubicin-induced cell death were evaluated by MTT method.

Natural Product Research published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Related Products of benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Zha, Gao-Feng published the artcilePalladium-Catalyzed Fluorosulfonylvinylation of Organic Iodides, Product Details of C8H5IO, the publication is Angewandte Chemie, International Edition (2017), 56(17), 4849-4852, database is CAplus and MEDLINE.

In the presence of Pd(OAc)₂, ethenesulfonyl fluoride underwent chemo-, regio- and diastereoselective aerobic Heck reactions with aryl, heteroaryl, and vinyl iodides mediated by silver trifluoroacetate in acetone to yield arylvinylsulfonyl fluorides such as (E)-PhCH:CHSO₂F and (E,E)-PhCH:CHCH:CHSO₂F in 24-99% yields. The structure of (E,E)-PhCH:CHCH:CHSO₂F was determined by x-ray crystallog.

Angewandte Chemie, International Edition published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C11H22N2O4, Product Details of C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem