In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 64169-67-1, name is 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, introducing its new discovery. COA of Formula: C15H10FNO
Recently, we published a synthesis of escitalopram (S-1) consisting of the resolution of didesmethylcitalopram (3) and subsequent methylation of S-didesmethylcitalopram (S-3) (Org. Process Res. De v. 2007, 11, 289-292). Some of our observations regarding citalopram resolution and C-alkylation of a benzofuran analogue (2) to produce didesmethylcitalopram (3) were disputed by Dr. Dancer of H. Lundbeck (preceding article). A detailed response to his comments regarding stabilization of the 3-chloroproylamine free base by dilution with certain solvents, its storage and handling, optimized experimental conditions for C-alkylation to prepare didesmethylcitalopram, and a corrected process for citalopram resolution are included.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 64169-67-1, and how the biochemistry of the body works.COA of Formula: C15H10FNO
Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3895O – PubChem