Phosphotungstic acid mediated, microwave assisted solvent-free green synthesis of highly functionalized 2′-spiro and 2, 3-dihydro quinazolinone and 2-methylamino benzamide derivatives from aryl and heteroaryl 2-amino amides was written by Novanna, Motakatla;Kannadasan, Sathananthan;Shanmugam, Ponnusamy. And the article was included in Tetrahedron Letters in 2019.Related Products of 54802-10-7 This article mentions the following:
Phosphotungstic acid has been found as green catalyst for the synthesis of spiro and cyclized quinazolinones and 2-amino substituted carboxamide under microwave irradiation and solvent-free condition. The scope of the reaction has been demonstrated for a variety of aldehydes and ketones with o-amino amides such as 2-aminobenzamide, 2-amino-5-iodobenzamide, 3-aminothiophene-2-carboxamide, 3-aminobenzofuran-2-carboxamide and 2-aminopyridine-3-carboxamide. The reaction afforded spiro-, cyclized quinazolinones and 2-amino substituted carboxamide derivatives within few minutes of irradiation in excellent yield. Plausible mechanism for the formation of products is provided. Synthetic utility of 1’H-spiro[fluorene-9,2′-quinazolin]-4′(3’H)-one 3a (I) has been demonstrated by synthesis of 1,4-di(1’H-spiro[fluorene-9,2′-quinazolin]-4′(3’H)-one) buta-1,3-diyne 12 (II), 1′-((1-benzyl-1H-1,2,3-triazol-4-yl) methyl)-1’H-spiro[fluorene-9,2′-quinazolin]-4′(3’H)-one 13 (III) and 1′-phenyl-1’H-spiro[fluorene-9,2′-quinazolin]-4′(3’H)-one 14 (IV) under standard protocols. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Related Products of 54802-10-7).
3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Related Products of 54802-10-7
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem