Cheruvu, Hanumanth Srikanth et al. published their research in Journal of Chromatography B in 2018 | CAS: 524-12-9

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Application of 524-12-9

LC-MS/MS method for the simultaneous quantification of luteolin, wedelolactone and apigenin in mice plasma using hansen solubility parameters for liquid-liquid extraction: Application to pharmacokinetics of Eclipta alba chloroform fraction was written by Cheruvu, Hanumanth Srikanth;Yadav, Navneet K.;Valicherla, Guru R.;Arya, Rakesh K.;Hussain, Zakir;Sharma, Chetan;Arya, Kamal R.;Singh, Rama K.;Datta, Dipak;Gayen, Jiaur R.. And the article was included in Journal of Chromatography B in 2018.Application of 524-12-9 The following contents are mentioned in the article:

Eclipta alba (Bhringraj) in ayurveda has been widely used as a traditional medicine for its multitherapeutic properties for ages. Luteolin (LTL), wedelolactone (WDL) and apigenin (APG) are the three main bioactive phytochems. present in Eclipta alba extract However there was a lack of sensitive bioanal. method for the pharmacokinetics of these free compounds in plasma which mainly contributes for their activities after oral administration of Eclipta alba. The present study aims to develop a sensitive, rapid and reliable liquid chromatog. tandem mass spectrometry (LC-MS/MS) method for the simultaneous estimation of mice plasma concentrations of LTL, WDL and APG using quercetin as an internal standard for the pharmacokinetic anal. Analytes were separated on Phenomenex Luna C18 (150 × 4.6 mm, 3.0 μm) column with mobile phase containing methanol: acetonitrile (90: 10, volume/volume) and 0.1% formic acid in 10 mM ammonium formate buffer in the ratio of 70: 30 (volume/volume) in isocratic mode. Liquid-liquid extraction was optimized using Hansen solubility parameters and di-Et ether finalized as an extraction solvent for the recovery ranging from 61 to 76% for all analytes in mice plasma. The validated method has an accuracy and precision over the linearity range of 0.1-200 ng/mL with a correlation coefficient (r2) of â‰?.997. The intra-and interday assay accuracy was between 98.17 and 107% and 95.83-107.89% resp. and the intra-and interday assay precision ranged from 0.37-6.05% and 1.85-10.76%, resp. for all the analytes. This validated method can be used for future clin. investigation studies of Eclipta alba extracts This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Application of 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Application of 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem